Endocrine Abstracts

Introduction: Thyroid hemiagenesis (TH) is characterised by congenital absence of one thyroid lobe.Aim: To assess possible association between TH and concomitant alterations of other structures derived from pharyngeal apparatus, which might potentially impact calcium-phosphate balance.Materials and methods: Studied group: 20 patients with TH. Control group: 20 subjects with bilobed thyroid, matched for age and gender. Serum concent...

Introduction: Thyroid hemiagenesis (TH) is a rare inborn anomaly presenting as developmental failure of one thyroid lobe. Recent research on the molecular background underlying thyroid dysgenesis have mainly focused on patients with congenital hypothyroidism. In contrast, subjects presenting TH were only sporadically involved. In addition, whether the same factors are responsible for development of TH and other forms of thyroid dysgenesis is still to be elucidated. Recent stud...

Thyroid hemiagenesis (TH) is a rare inborn anomaly presenting as failure of the development of one thyroid lobe. Recent research on the molecular background underlying thyroid dysgenesis have mainly focused on patients with congenital hypothyroidism; in contrast, subjects presenting TH were only sporadically involved. Changes in transcription factor genes, including TTF1, TTF2 and PAX8, which play an important role in thyroid embryogenesis, have been postu...

Severe thyroid disorder are associated with important metabolic changes. After restoration of euthyroidism, as a result of proper treatment, usually body metabolism also normalizes. Up to date, there are conflicting reports about the changes in body composition of patients during treatment of severe hyperthyroidism and hypothyroidism. The aim of this study was to evaluate the body composition and glucose level changes in subjects affected by Graves disease and autoimmune thyro...

Purpose: Acromegaly is a disease characterized by the excessive secretion of GH. Clinically, it is manifested by overgrowth of tissues and internal organs, which leads to characteristic phenotype. Patients with active acromegaly usually have impaired glucose metabolism. It significantly improves after achieving remission of the disease. Adversely, disturbances in lipid profile are not altering. Moreover, these parameters are even worse in successfully treated patients. Ghrelin...

The waist-to-height ratio (WHtR) has recently gained attention as an anthropometric index showing the highest predictive value for cardiometabolic risk in PCOS and healthy women. Central adiposity is the key driving force behind a constellation of inflammatation linked to insulin resistance, metabolic syndrome and cardiovascular diseases. PCOS is also considered to be linked to chronic inflammatory processes. Platelet count ratio/mean platelet volume (PLT/MPV), lymphocyte&#150...

IntroductionHepcidin, main body iron regulator protein, decreases iron concentration available for erythropoiesis. Oppositely, excessive erythropoiesis in acromegaly patients (increased GH and IGF-1), may inhibit hepcidin production. GH stimulates bone marrow, whereas IGF-1 receptors are expressed in erythrocytes. Exogenous GH administration in healthy subjects reduced hepcidin level. The role of hepcidin in iron metabolism of acromegaly patients has not...

Background: Graves disease with elevated Immunoglobulin G4 serum concentration is a novel subtype of Graves disease (GD), which seems to be particularly associated with Graves orbitopathy (GO). It occurs in 17.6% of patients with GO and 5.4% of patients with GD without GO. In this study, we compare multiple magnetic resonance imaging (MRI) features of GO with elevated IgG4 serum concentration (IgG4-GO) with the classic GO subtype without IgG4 elevation. No such research has be...

Introduction: Impaired insulin sensitivity accompanies polycystic ovary syndrome (PCOS). Women with PCOS are usually at risk of premature cardiovascular disease, which increases with age and body weight. We studied the link between insulin sensitivity measured by the Matsuda Insulin Sensitivity Index (MISI) adjusted to body mass index (BMI) and age in otherwise healthy PCOS women.Methods: 250 adult women with PCOS of reproductive age (18-43 years old) un...

Introduction: Obstructive sleep apnea syndrome (OSAS) is characterized by chronic inflammation. Hepcidin is an acute-phase protein involved in iron metabolism. Increase in hepcidin has been shown in OSAS. Testosterone probably exerts inhibitory effect on hepcidin levels and even trump iron and inflammation-mediated mechanism in chronic inflammatory state. On the other hand iron balance may influence gonadal axis. The aim of this study was to assess whether hypogonadism in OSAS...